Changes in Nicotinic Neurotransmission during Enteric Nervous System Development
نویسندگان
چکیده
منابع مشابه
IL-1beta and IL-6 excite neurons and suppress nicotinic and noradrenergic neurotransmission in guinea pig enteric nervous system.
Conventional intracellular microelectrodes and injection of biocytin were used to study the actions of IL-1beta and IL-6 on electrical and synaptic behavior in morphologically identified guinea pig small intestinal submucous neurons. Exposure to nanomolar concentrations of either IL-1beta or IL-6 stimulated neuronal excitability. The excitatory action consisted of depolarization of the membrane...
متن کاملIL-1β and IL-6 excite neurons and suppress nicotinic and noradrenergic neurotransmission in guinea pig enteric nervous system
IL-1β and IL-6 are proinflammatory cytokines that share several common biologic properties (1). They are expressed by a variety of cell types, but mainly they are made by monocytes and macrophages in response to a broad spectrum of stimuli including microbial derivatives, immune complexes, activated T cells, integrated actions of other cytokines, and psychogenic or environmental stress. Both cy...
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Development of the ENS requires the function of a diverse set of genes encoding transcription factors, signaling molecules, and their receptors. Mutations of these genes result in altered ENS function in animals and humans. In particular, such mutations have been shown to contribute to many cases of Hirschsprung's disease. Elucidation of the mechanisms of ENS development and function allow the ...
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The enteric nervous system (ENS) is composed of neurons and glia that modulate many aspects of intestinal function. The ability to use both forward and reverse genetic approaches and to visualize development in living embryos and larvae has made zebrafish an attractive model in which to study mechanisms underlying ENS development. In this chapter, we review the recent work describing the develo...
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As we enter the 21 century, the segment of the population that is the most rapidly expanding is that comprised of individuals 85 years of age and older. Dysfunctions of the gastrointestinal (GI) system, including dysphagia, constipation, diarrhea, and irritable bowel syndrome are more common complaints of the elderly, yet our knowledge of the aging GI tract is incomplete. Compared to the rapid ...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2015
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.4175-14.2015